New in Guangzhou on December 18. in the fourth, 18th reporters from Guangzhou Guangzhou International stem cell and regenerative medicine Forum was informed that China research team started on the forums using induced pluripotent stem cell technology gene repair after Eastern Mediterranean anemia in patients with hematopoietic stem cell project, obtained through own stem cells in vitro repair of patients with radical. Included in the 2012 national important research project in China.
According to project Chief Scientist, Dr Guangzhou Institute of biomedicine and Health Pan Guangjin said within the next 5 years, Guangzhou Institute of biomedicine and health, Chinese Academy of Sciences, Institute of Zoology, Chinese Academy of Sciences, Southern Medical University Hospital in the South, Hainan Medical College and other units of experts will adopt the induced pluripotent stem cell research, seeking the treatment of common monogenic genetic disease--Eastern Mediterranean anemia in new ways.
Eastern Mediterranean anaemia is a global common chronic hemolytic anemia.In China, the Eastern Mediterranean anemia are mainly distributed in Sichuan, Yunnan, Guizhou, Fujian, Guangdong and other provinces South of the Yangtze River basin.
In recent years, the Eastern Mediterranean anemia better treatment method is the use of hematopoietic stem cell transplantation. Eastern Mediterranean anemia due to bone marrow hyperplasia, active, easy only normally take more blood-forming stem cells implantation, this greatly limits the mass of this treatment and increase the cost of treatment.
So, the scientists "to target" in recent years the rise of induced pluripotent stem cells. Pan Guangjin, induced pluripotent stem cell technology in the treatment of this starts to lean projects is the use of novel non-viral technique, by reprogramming adult cells, allowing cells to pluripotent stem cells, regained the ability to differentiate into a variety of cells. Project groups will be the patient's skin cells into pluripotent stem cells, and then through the in-situ remediation of disease genes, further blood stem cells differentiate into functional and eventually for transplantation in the treatment of and thus thoroughly remedy the Eastern Mediterranean anaemia, and be able to use yupajinsen syndrome, treatment of diseases such as Alzheimer 's.
Pan Guangjin stressed that this technology is the source of a patient's own cells for transplant, it will not generate exclusion, reducing the cost of hospital treatment and care, and new treatment costs may only about one-fifth of traditional therapies. He also said that if we can successfully prove that this treatment works, it will rapidly widely used at the clinical.
It is learnt that the end of 2007, the Guangzhou Institute of biomedicine and health succeed in induced pluripotent stem cells, following Japan and the United States third after mastering the technical state.
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